Journal article
Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees
- Abstract:
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A major challenge in evaluating the contribution of rare variants to complex disease is identifying enough copies of the rare alleles to permit informative statistical analysis. To investigate the contribution of rare variants to the risk of type 2 diabetes (T2D) and related traits, we performed deep whole-genome analysis of 1,034 members of 20 large Mexican-American families with high prevalence of T2D. If rare variants of large effect accounted for much of the diabetes risk in these familie...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Accepted manuscript, zip, 1.7MB)
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(Accepted manuscript, pdf, 371.2KB)
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(Accepted manuscript, pdf, 175.3KB)
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- Publisher copy:
- 10.1073/pnas.1705859115
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Authors
Funding
+ National Institutes of Health
More from this funder
Grant:
RC2-DK08839, DK105535, DK085524, DK085545, DK085584, DK085501, DK098032, DK078616, DK085526
Bibliographic Details
- Publisher:
- National Academy of Sciences Publisher's website
- Journal:
- Proceedings of the National Academy of Sciences Journal website
- Volume:
- 115
- Issue:
- 2
- Pages:
- 379-384
- Publication date:
- 2018-01-09
- Acceptance date:
- 2017-11-28
- DOI:
- EISSN:
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1091-6490
- ISSN:
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0027-8424
- Pmid:
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29279374
- Source identifiers:
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813025
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:813025
- UUID:
-
uuid:581a648c-d8bc-4c1f-9c8a-b212e9d6c747
- Local pid:
- pubs:813025
- Deposit date:
- 2018-01-23
Terms of use
- Copyright holder:
- Jun et al
- Copyright date:
- 2018
- Notes:
- This is the author accepted manuscript following peer review version of the article. The final version is available online from National Academy of Sciences at: 10.1073/pnas.1705859115
- Licence:
- Other
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