Abstract:

Among the hundreds of ligands for heparan sulfate (HS) are chemokines, cytokines, and growth factors, giving this proteoglycan a potentially central role in the regulation of immune responses. The biosynthesis of HS is regulated during inflammation with consequent changes to ligand binding and activity in multiple cell types including myeloid cells. In this thesis, I aimed to comprehensively describe the changes in expression of HS core proteins and biosynthetic enzymes in human primary mo...

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