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Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages.

Abstract:

To examine the pathogenic role of α-synuclein (αS) in Parkinson's Disease, we have generated induced Pluripotent Stem Cell lines from early onset Parkinson's Disease patients with SNCA A53T and SNCA Triplication mutations, and in this study have differentiated them to PSC-macrophages (pMac), which recapitulate many features of their brain-resident cousins, microglia. We show that SNCA Triplication pMac, but not A53T pMac, have significantly increased intracellular αS versus controls and relea...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-09362-3

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
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Oxford Martin School More from this funder
National Institute for Health Research More from this funder
US Federal Government More from this funder
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Pages:
9003
Publication date:
2017-08-01
Acceptance date:
2017-07-24
DOI:
ISSN:
2045-2322
Pmid:
28827786
Source identifiers:
724029
Language:
English
Keywords:
Subjects:
Pubs id:
pubs:724029
UUID:
uuid:584ca9e8-2170-4293-a44f-b75e37c17825
Local pid:
pubs:724029
Deposit date:
2017-09-25

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