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Diabetic mitochondria are resistant to palmitoyl CoA inhibition of respiration, which is detrimental during ischemia

Abstract:

The bioactive lipid intermediate palmitoyl CoA (PCoA) can inhibit mitochondrial ADP/ATP transport, though the physiological relevance of this regulation remains unclear. We questioned whether myocardial ischemia provides a pathological setting in which PCoA regulation of ADP/ATP transport would be beneficial, and secondly, whether the chronically elevated lipid content within the diabetic heart could make mitochondria less sensitive to the effects of PCoA. PCoA acutely decreased ADP-stimulate...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1096/fj.202100394r

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Publisher:
Federation of American Society of Experimental Biology Publisher's website
Journal:
FASEB Journal Journal website
Volume:
35
Issue:
8
Article number:
e21765
Publication date:
2021-07-28
Acceptance date:
2021-06-14
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Pmid:
34318967
Language:
English
Keywords:
Pubs id:
1188862
Local pid:
pubs:1188862
Deposit date:
2021-08-05

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