Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells
Activation of the group 2 innate lymphoid cell (ILC2) population leads to production of the classical type 2 cytokines, thus promoting type 2 immunity. Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), a receptor for prostaglandin D2 (PGD2), is expressed in human ILC2. However, the function of CRTH2 in these cells is unclear.
We sought to determine the role of PGD2 and CRTH2 in human ILC2 and compare it with that of ...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Accepted manuscript, pdf, 323.6KB)
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- Copyright holder:
- Ogg et al
- Copyright date:
- © 2013 The Authors. Published by Elsevier Inc. Open access under CC BY-NC-ND license.
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