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Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

Abstract:

Background

Activation of the group 2 innate lymphoid cell (ILC2) population leads to production of the classical type 2 cytokines, thus promoting type 2 immunity. Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2), a receptor for prostaglandin D2 (PGD2), is expressed in human ILC2. However, the function of CRTH2 in these cells is unclear.

Objectives

We sought to determine the role of PGD2 and CRTH2 in human ILC2 and compare it with that of ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jaci.2013.10.056

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More from this funder
Funding agency for:
Klenerman, P
More from this funder
Funding agency for:
Klenerman, P
More from this funder
Funding agency for:
Xue, L
Ogg, G
Klenerman, P
Publisher:
Elsevier Publisher's website
Journal:
Journal of Allergy and Clinical Immunology Journal website
Volume:
133
Issue:
4
Pages:
1184-1194.e7
Publication date:
2013-12-01
Acceptance date:
2013-10-28
DOI:
EISSN:
1097-6825
ISSN:
0091-6749
Keywords:
Pubs id:
pubs:462662
UUID:
uuid:5882c732-0862-474b-845c-b0f41bf292ba
Local pid:
pubs:462662
Source identifiers:
462662
Deposit date:
2014-07-11

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