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Selective inhibitors of a human prolyl hydroxylase (OGFOD1) involved in ribosomal decoding

Abstract:

Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. Here we report a structurally informed template‐based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, in...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/chem.201804790

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Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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More from this funder
Funding agency for:
Lohans, C
Grant:
Early Career Fellowship
Publisher:
Wiley Publisher's website
Journal:
Chemistry - A European Journal Journal website
Volume:
25
Issue:
8
Pages:
2019-2024
Publication date:
2018-11-14
Acceptance date:
2018-11-14
DOI:
EISSN:
1521-3765
ISSN:
0947-6539
Keywords:
Pubs id:
pubs:942643
UUID:
uuid:5890cb84-7bfb-4f4c-aaf0-394fa42dcb19
Local pid:
pubs:942643
Deposit date:
2018-11-15

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