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Navigating critical challenges associated with immunopeptidomics-based detection of proteasomal spliced peptide candidates

Abstract:

Within the tumor immunology community, the topic of proteasomal spliced peptides (PSP) has generated a great deal of controversy. In the earliest reports, careful biological validation led to the conclusion that proteasome-catalyzed peptide splicing was a rare event. To date, six PSPs have been validated biologically. However, the advent of algorithms to identify candidate PSPs in mass spectrometry data challenged this notion, with several studies concluding that the frequency of spliced pept...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-2761-2803
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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
ORCID:
0000-0002-4995-3270
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Immunology Research Journal website
Volume:
10
Issue:
3
Pages:
275–284
Publication date:
2022-02-01
Acceptance date:
2022-01-14
DOI:
EISSN:
2326-6074
ISSN:
2326-6066
Language:
English
Keywords:
Pubs id:
1237535
Local pid:
pubs:1237535
Deposit date:
2022-02-16

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