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Risk alleles for multiple sclerosis in multiplex families.

Abstract:

OBJECTIVE: We assessed the hypotheses that non-major histocompatibility complex multiple sclerosis (MS) susceptibility loci would be common to sporadic cases and multiplex families, that they would have larger effects in multiplex families, and that the aggregation of susceptibility loci contributes to the increased prevalence of MS in such families. METHODS: A set of 43 multiplex families comprising 732 individuals and 211 affected subjects was genotyped for 13 MS candidate genes identified...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Neurology
Volume:
72
Issue:
23
Pages:
1984-1988
Publication date:
2009-06-01
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
Source identifiers:
34746

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