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Evidence for a second ankylosing spondylitis-associated RUNX3 regulatory polymorphism

Abstract:

To explore the functions of RUNX3 single nucleotide polymorphisms (SNPs) associated with ankylosing spondylitis (AS).Individual SNP associations were evaluated in 4230 UK cases. Their effects on transcription factor (TF) binding, transcription regulation, chromatin modifications, gene expression and gene interactions were tested by database interrogation, luciferase reporter assays, electrophoretic mobility gel shifts, chromatin immunoprecipitation and real-time PCR.We confirmed the independe...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/rmdopen-2017-000628

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Role:
Author
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Funding agency for:
Vecellio, M
Grant:
21428
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Funding agency for:
Vecellio, M
Grant:
21428
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Funding agency for:
Roberts, A
Grant:
20402
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Funding agency for:
Knight, J
Grant:
Oxford Comprehensive Biomedical Research Centre
More from this funder
Funding agency for:
Knight, J
Grant:
Oxford Comprehensive Biomedical Research Centre
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Publisher:
BMJ Publishing Group Publisher's website
Journal:
RMD Open Journal website
Volume:
4
Issue:
1
Article number:
e000628
Publication date:
2018-02-08
Acceptance date:
2018-01-16
DOI:
ISSN:
2056-5933
Pmid:
29531791
Source identifiers:
830215
Language:
English
Keywords:
Pubs id:
pubs:830215
UUID:
uuid:5909a4f9-a4e0-465b-97b5-f10fc74d6ba6
Local pid:
pubs:830215
Deposit date:
2018-04-04

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