Journal article
Structure of three tandem filamin domains reveals auto-inhibition of ligand binding
- Abstract:
-
Human filamins are large actin-crosslinking proteins composed of an N-terminal actin-binding domain followed by 24 Ig-like domains (IfFLNs), which interact with numerous transmembrane receptors and cytosolic signaling proteins. Here we report the 2.5 Å resolution structure of a three-domain fragment of human filamin A (IgFLNa19-21). The structure reveals an unexpected domain arrangemetn, with IgFLNa20 partially unfolded bringing IgFLNa21 into close proximity to IgFLNa19. Notably the N-terminu...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Version of record, pdf, 445.5KB)
-
(Version of record, pdf, 1.7MB)
-
- Publisher copy:
- 10.1038/sj.emboj.7601827
Authors
Contributors
+ European Molecular Biology Organization
Institution:
University of Oxford
Role:
Other
Funding
+ National Institutes of Health
More from this funder
Funding agency for:
Calderwood, D
Grant:
ROI GM068600-01
CSC - the Finnish IT Centre for Science
More from this funder
Bibliographic Details
- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- EMBO Journal Journal website
- Volume:
- 26
- Issue:
- 17
- Pages:
- 3993-4004
- Publication date:
- 2007-09-01
- DOI:
- ISSN:
-
1460-2075
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:593888b0-7bdb-4588-a3df-8acc77db2121
- Local pid:
- ora:3162
- Deposit date:
- 2009-12-15
Related Items
Terms of use
- Copyright holder:
- European Molecular Biology Organization
- Copyright date:
- 2007
- Notes:
- Citation: Lad, Y. et al. (2007). 'Structure of three tandem filamin domains reveals auto-inhibition of ligand binding', The EMBO Journal, 26(17), 3993-4004. [Available at http://www.nature.com/emboj/index.html]. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission.
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record