The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations.

Journal article

Dengue fever is the most important mosquito-borne viral disease of humans with more than 50 million cases estimated annually in more than 100 countries. Disturbingly, the geographic range of dengue is currently expanding and the severity of outbreaks is increasing. Control options for dengue are very limited and currently focus on reducing population abundance of the major mosquito vector, Aedes aegypti. These strategies are failing to reduce dengue incidence in tropical communities and there...

Expand abstract

Authors: Walker, T; Johnson, P; Moreira, L; Iturbe-Ormaetxe, I; Frentiu, F

• Journal: Nature
• Volume: 476
• Issue: 7361
• Pages: 450-453
• Publication date: 2011-08-01
• DOI: 10.1038/nature10355
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Pest Control, Biological; Humans; Animals; Wolbachia; Insect Vectors; Female; Dengue Virus; Male; Aedes; Reproduction; Saliva; Genetic Fitness; Dengue