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Activated invariant NKT cells regulate osteoclast development and function.

Abstract:

Invariant NKT (iNKT) cells modulate innate and adaptive immune responses through activation of myeloid dendritic cells and macrophages and via enhanced clonogenicity, differentiation, and egress of their shared myeloid progenitors. Because these same progenitors give rise to osteoclasts (OCs), which also mediate the egress of hematopoietic progenitors and orchestrate bone remodeling, we hypothesized that iNKT cells would extend their myeloid cell regulatory role to the development and functio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.4049/jimmunol.1002353

Authors


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Medical Research Council More from this funder
Leukaemia and Lymphoma Research More from this funder
Arthritis Research Campaign More from this funder
Publisher:
American Association of Immunologists Publisher's website
Journal:
Journal of Immunology Journal website
Volume:
186
Issue:
5
Pages:
2910-2917
Publication date:
2011-01-01
Acceptance date:
2010-12-23
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
223543

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