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ImmunoglobuliN in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial.

Abstract:

INTRODUCTION: Infectious and immune-mediated encephalitides are important but under-recognised causes of morbidity and mortality in childhood, with a 7% death rate and up to 50% morbidity after prolonged follow-up. There is a theoretical basis for ameliorating the immune response with intravenous immunoglobulin (IVIG), which is supported by empirical evidence of a beneficial response following its use in the treatment of viral and autoimmune encephalitis. In immune-mediated encephalitis, IVIG...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1136/bmjopen-2016-012356

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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Paediatrics
Role:
Author
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Grant:
MechanismEvaluationprogramme,anMRC
Efficacy
NIHRpartnership(projectnumber(12/212/15
Publisher:
BMJ Publishing Group Publisher's website
Journal:
BMJ Open Journal website
Volume:
6
Issue:
11
Publication date:
2016-11-03
Acceptance date:
2016-08-19
DOI:
EISSN:
2044-6055
ISSN:
2044-6055
Source identifiers:
657910
Language:
English
Keywords:
Pubs id:
pubs:657910
UUID:
uuid:598bf396-1104-4ec5-8b48-5925d44c9992
Local pid:
pubs:657910
Deposit date:
2016-11-12

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