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CHAP: A versatile tool for the structural and functional annotation of ion channel pores

Abstract:

The control of ion channel permeation requires the modulation of energetic barriers or "gates" within their pores. However, such barriers are often simply identified from the physical dimensions of the pore. Such approaches have worked well in the past,but there is now evidence that the unusual behaviour of water within narrow hydrophobic pores can produce an energetic barrier to permeation without requiring steric occlusion of the pathway. Many different ion channels have now been shown to e...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jmb.2019.06.003

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
Christ Church
Role:
Author
ORCID:
0000-0001-6360-7959
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Oxford college:
Green Templeton College
Role:
Author
ORCID:
0000-0001-8996-2000
Publisher:
Elsevier Publisher's website
Journal:
Journal of Molecular Biology Journal website
Volume:
431
Issue:
17
Pages:
3353-3365
Publication date:
2019-06-17
Acceptance date:
2019-06-04
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
Pmid:
31220459
Source identifiers:
1026634
Language:
English
Keywords:
Pubs id:
pubs:1026634
UUID:
uuid:59c5e4e4-cdb0-4dd4-b825-f6e4aa70013e
Local pid:
pubs:1026634
Deposit date:
2019-07-04

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