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Journal article

Antibody opsonization enhances MAIT cell responsiveness to bacteria via a TNF-dependent mechanism

Abstract:

Mucosal-associated invariant T (MAIT) cells are an abundant human T cell subset with anti-microbial properties. They can respond to bacteria presented via antigen-presenting cells (APCs) such as macrophages, which present bacterially derived ligands from the riboflavin synthesis pathway on MR1. Moreover, MAIT cells are also highly responsive to cytokines which enhance and even substitute for TCR-mediated signaling. The mechanisms leading to an efficient presentation of bacteria to MAIT cells ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/imcb.12239

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
NDM Experimental Medicine
Oxford college:
Green Templeton College
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Immunology and Cell Biology Journal website
Volume:
97
Issue:
6
Pages:
538-551
Publication date:
2019-01-29
Acceptance date:
2019-01-23
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Source identifiers:
966626
Keywords:
Pubs id:
pubs:966626
UUID:
uuid:5a0b94f4-ab8b-4b40-9c5c-7b46f2c13541
Local pid:
pubs:966626
Deposit date:
2019-01-28

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