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Thesis

Aspirin affects early phases of metastasis through the inhibition of COX-1-thromboxane A2 axis

Abstract:

Metastasis is the major cause of cancer related mortality, due to a poor understanding of the metastatic process and a subsequent lack of effective anti-metastatic therapies. Evidence from experimental studies and clinical trials has shown that aspirin reduces the incidence of distant metastases. It is well established that aspirin inhibits cyclooxygenase (COX)-1 and COX-2, triggering anti-thrombotic and anti-inflammatory effects, respectively. However, the mechanisms underlying the anti-m...

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
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Funding agency for:
Lucotti, S
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
UUID:
uuid:5a12480c-6b8a-4f46-b38a-4b59122e9280
Deposit date:
2017-10-26

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