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Journal article

Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells.

Abstract:

Apolipoproteins L (ApoLs) are Bcl-2-like proteins expressed under inflammatory conditions in myeloid and endothelial cells. We found that Toll-like receptor (TLR) stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), specifically induce ApoLs7/11 subfamilies in murine CD8α(+)  dendritic cells (DCs). This induction requires the TLR3/TRIF (where TRIF is TIR domain containing adapter-inducing interferon β) signaling pathway and is dependent on IFN-β in all ApoLs su...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/eji.201546252

Authors


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Walloon Region More from this funder
Belgian National Fund for Scientific Research More from this funder
European Regional Development Fund More from this funder
Publisher:
Wiley Publisher's website
Journal:
European Journal of Immunology Journal website
Volume:
46
Issue:
8
Pages:
1854-1866
Publication date:
2016-05-01
Acceptance date:
2016-05-12
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Pmid:
27198486
Source identifiers:
809050

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