Mechanistic modelling to determine the limits of clinical and pre-clinical cancer immunotherapies

Thesis

Immune-mediated clearance of a tumour is predicated on successful activation, migration and engagement of cytotoxic CD8+ T-cells. There are numerous factors that may impede these processes and that vary considerably between patients. In this thesis, I describe the use of mechanistic models to quantify and identify mechanisms that limit immune responses and immunotherapeutics against tumours. I describe the use of a model of T-cell activation in the lymph node to quantify the impact of pati...

Expand abstract

Authors: Brown, L

• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: University of Oxford
• Language: English
• Keywords: CAR; T-cell; Clinical trial; Trafficking
• Subjects: Immunology--Mathematical models; Mathematical Biology; Cancer--Mathematical models