Thesis icon

Thesis

Mechanistic modelling to determine the limits of clinical and pre-clinical cancer immunotherapies

Abstract:

Immune-mediated clearance of a tumour is predicated on successful activation, migration and engagement of cytotoxic CD8+ T-cells. There are numerous factors that may impede these processes and that vary considerably between patients. In this thesis, I describe the use of mechanistic models to quantify and identify mechanisms that limit immune responses and immunotherapeutics against tumours. I describe the use of a model of T-cell activation in the lymph node to quantify the impact of pati...

Expand abstract

Actions


Access Document


Files:

Authors


More by this author
Division:
MPLS
Department:
Mathematical Institute
Role:
Author

Contributors

Role:
Supervisor
Role:
Supervisor
Hoffman-La Roche More from this funder
Clarendon Fund More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:5a576e33-a9a6-4caf-9f2e-f1d910328bbf
Deposit date:
2019-08-25

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP