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Journal article

Contrasting effects of phosphatidylinositol 4,5-bisphosphate (PIP2 ) on cloned TMEM16A and TMEM16B channels

Abstract:

Background and Purpose

Ca2+-activated Cl- channels (CaCCs) are gated open by a rise in intracellular Ca2+ concentration ([Ca2+]i), typically provoked by activation of Gq-protein coupled receptors (GqPCR). GqPCR activation initiates depletion of plasmalemmal phosphatidylinositol 4,5-bisphosphate (PIP2). Here, we determined whether PIP2 acts as a signalling lipid for CaCCs coded by the TMEM16A and TMEM16B genes.

Experimental Approach

Patch-clamp electrophysiology, i...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/bph.13913

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Doctoral Training Centre - MPLS
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Queens College
Role:
Author
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Grant:
DPhil studentship
Publisher:
Wiley Publisher's website
Journal:
British Journal of Pharmacology Journal website
Volume:
174
Issue:
18
Pages:
2984–2999
Publication date:
2017-06-01
Acceptance date:
2017-06-10
DOI:
EISSN:
1476-5381
ISSN:
0007-1188
Pubs id:
pubs:702853
UUID:
uuid:5a7ff85f-2758-4cdb-9527-555cba00de24
Local pid:
pubs:702853
Deposit date:
2017-09-07

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