Journal article
Contrasting effects of phosphatidylinositol 4,5-bisphosphate (PIP2 ) on cloned TMEM16A and TMEM16B channels
- Abstract:
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Background and Purpose
Ca2+-activated Cl- channels (CaCCs) are gated open by a rise in intracellular Ca2+ concentration ([Ca2+]i), typically provoked by activation of Gq-protein coupled receptors (GqPCR). GqPCR activation initiates depletion of plasmalemmal phosphatidylinositol 4,5-bisphosphate (PIP2). Here, we determined whether PIP2 acts as a signalling lipid for CaCCs coded by the TMEM16A and TMEM16B genes.
Experimental Approach
Patch-clamp electrophysiology, i...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(pdf, 1.5MB)
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- Publisher copy:
- 10.1111/bph.13913
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Authors
Funding
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- British Journal of Pharmacology Journal website
- Volume:
- 174
- Issue:
- 18
- Pages:
- 2984–2999
- Publication date:
- 2017-06-01
- Acceptance date:
- 2017-06-10
- DOI:
- EISSN:
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1476-5381
- ISSN:
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0007-1188
Item Description
- Pubs id:
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pubs:702853
- UUID:
-
uuid:5a7ff85f-2758-4cdb-9527-555cba00de24
- Local pid:
- pubs:702853
- Deposit date:
- 2017-09-07
Terms of use
- Copyright holder:
- Tammaro et al
- Copyright date:
- 2017
- Notes:
- © 2017 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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