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Thesis

DNA damage repair proteins as determinants of sensitivity to platinum chemotherapy

Abstract:

DNA damage repair proteins are determinants of sensitivity to platinum chemotherapy in preclinical models and in patients with cancer. The XPF- ERCC1 heterodimer incises DNA strands adjacent to platinum-DNA adducts and is essential for repair of platinum-DNA interstrand cross-links (ICLs). High expression of ERCC1 has been correlated with lack of response to platinum chemotherapy, but less is known about the value of XPF in predicting response to platinum-based chemotherapy. MUS81- EME1 is...

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Division:
MSD
Department:
Oncology
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Supervisor
ORCID:
0000-0003-0167-1685
National Institute for Health Research More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford

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