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Journal article

VEGF regulates local inhibitory complement proteins in the eye and kidney

Abstract:

Outer retinal and renal glomerular functions rely on specialized vasculature maintained by VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) and podocytes, respectively. Dysregulation of RPE- and podocyte-derived VEGF is associated with neovascularization in wet age-related macular degeneration (ARMD), choriocapillaris degeneration, and glomerular thrombotic microangiopathy (TMA). Since complement activation and genetic variants in inhibitory compleme...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1172/JCI86418

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Publisher:
American Society for Clinical Investigation Publisher's website
Journal:
Journal of Clinical Investigation Journal website
Volume:
127
Issue:
1
Pages:
199-214
Publication date:
2016-12-05
Acceptance date:
2016-10-28
DOI:
EISSN:
1558-8238
ISSN:
0021-9738
Pmid:
27918307
Source identifiers:
671762
Language:
English
Pubs id:
pubs:671762
UUID:
uuid:5a9ea057-38c3-46bc-9570-f5709ae0c1b8
Local pid:
pubs:671762
Deposit date:
2019-02-13

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