Journal article
VEGF regulates local inhibitory complement proteins in the eye and kidney
- Abstract:
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Outer retinal and renal glomerular functions rely on specialized vasculature maintained by VEGF that is produced by neighboring epithelial cells, the retinal pigment epithelium (RPE) and podocytes, respectively. Dysregulation of RPE- and podocyte-derived VEGF is associated with neovascularization in wet age-related macular degeneration (ARMD), choriocapillaris degeneration, and glomerular thrombotic microangiopathy (TMA). Since complement activation and genetic variants in inhibitory compleme...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 3.2MB)
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- Publisher copy:
- 10.1172/JCI86418
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Authors
Bibliographic Details
- Publisher:
- American Society for Clinical Investigation Publisher's website
- Journal:
- Journal of Clinical Investigation Journal website
- Volume:
- 127
- Issue:
- 1
- Pages:
- 199-214
- Publication date:
- 2016-12-05
- Acceptance date:
- 2016-10-28
- DOI:
- EISSN:
-
1558-8238
- ISSN:
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0021-9738
- Pmid:
-
27918307
- Source identifiers:
-
671762
Item Description
- Language:
- English
- Pubs id:
-
pubs:671762
- UUID:
-
uuid:5a9ea057-38c3-46bc-9570-f5709ae0c1b8
- Local pid:
- pubs:671762
- Deposit date:
- 2019-02-13
Terms of use
- Copyright holder:
- Keir et al
- Copyright date:
- 2016
- Notes:
- This work is licensed under the Creative Commons Attribution 4.0 International License.
- Licence:
- CC Attribution (CC BY)
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