Biochemical and biophysical studies of the prokaryotic proton dependent oligopeptide transporters

Thesis

The proton dependent oligopeptide transporters (POT family) are members of the Major Facilitator Superfamily of secondary active transporter proteins. They use the transmembrane proton gradient to drive the uptake of di- and tripeptides into the cytoplasm. Members of the family are highly conserved in pro- and eukaryotic genomes, and in humans they are responsible for the oral absorption of many drug families, including β-lactam antibiotics. Recently, the crystal structures of PepT_So...

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Authors: Solcan, N

• Publication date: 2013
• Type of award: DPhil
• Level of award: Doctoral
• Awarding institution: Oxford University, UK
• Language: English
• Keywords: Structural Biology; Membrane proteins; Membrane transport; Biochemistry
• Subjects: Molecular biophysics (biochemistry); Protein chemistry; Membrane proteins; NMR spectroscopy; Metabolism; Epithelial Transport; Biochemistry; Crystallography; Spectroscopy and molecular structure