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Modifying membrane morphology and interactions with DNA origami clathrin-mimic networks

Abstract:

We describe the triggered assembly of a bio-inspired DNA origami meshwork on a lipid membrane. DNA triskelia, three-armed DNA origami nanostructures inspired by the membrane-modifying protein clathrin, are bound to lipid mono- and bi-layers using cholesterol anchors. Polymerization of triskelia, triggered by the addition of DNA staples, links triskelion arms to form a mesh. Using transmission electron microscopy, we observe nanoscale local deformation of a lipid monolayer induced by triskelio...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1021/acsnano.8b07734

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More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry
Oxford college:
Wadham College
Role:
Author
ORCID:
0000-0002-5692-8313
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Oxford college:
Magdalen College
Role:
Author
ORCID:
0000-0002-3876-0190
Publisher:
American Chemical Society Publisher's website
Journal:
ACS Nano Journal website
Volume:
13
Issue:
9
Pages:
9973-9979
Publication date:
2019-08-20
Acceptance date:
2019-08-16
DOI:
EISSN:
1936-086X
ISSN:
1936-0851
Pmid:
31418553
Source identifiers:
1046650
Language:
English
Keywords:
Pubs id:
pubs:1046650
UUID:
uuid:5adc8345-8753-40b5-be89-1a2ef85a4d5d
Local pid:
pubs:1046650
Deposit date:
2019-08-21

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