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A pivotal role for cADPR-mediated Ca2+ signaling: regulation of endothelin-induced contraction in peritubular smooth muscle cells.

Abstract:

cADPR, a potent calcium-mobilizing intracellular messenger synthesized by ADP-ribosyl cyclases regulates openings of ryanodine receptors (RyR). Here we report that in the rat testis, a functional cADPR Ca2+ release system is essential for the contractile response of peritubular smooth muscle cells (PSMC) to endothelin (ET). We previously showed that this potent smooth muscle agonist elicits intracellular Ca2+ release in PSMC and seminiferous tubule contraction via activation of ETA and ETB re...

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Publication status:
Published

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Publisher copy:
10.1096/fj.01-0749com

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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Journal:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume:
16
Issue:
7
Pages:
697-705
Publication date:
2002-05-01
DOI:
EISSN:
1530-6860
ISSN:
0892-6638
Source identifiers:
106526

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