Thesis
Studies on an N-terminal nucleophile hydrolase and enzymes of clavulanic acid biosynthesis
- Abstract:
-
(3R,5R)-Clavulanic acid is a clinically important inhibitor of Class A β-lactamases. Progress has been made in to establishing the steps of clavulanic acid biosynthesis leading to (3S,5S)-clavaminic acid. However, the mechanism by which (3S,5S)-clavaminic acid is converted to the penultimate intermediate (3R,5R)-clavaldehyde remains elusive. It is believed that the products of the later genes (orf10-orf18) of the clavulanic acid biosynthesis gene cluster are probably involved in this conve...
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Bibliographic Details
- Publication date:
- 2008
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:5ae868c0-007b-4cb8-b4cf-21ab93f69281
- Local pid:
- ora:11445
- Deposit date:
- 2015-05-14
Terms of use
- Copyright holder:
- Aman Iqbal
- Copyright date:
- 2008
- Notes:
- This thesis is not currently available in ORA
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