Journal article icon

Journal article

Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2

Abstract:

Enterovirus 71 (EV71) is a common cause of hand, foot and mouth disease—a disease endemic especially in the Asia-Pacific region1. Scavenger receptor class B member 2 (SCARB2) is the major receptor of EV71, as well as several other enteroviruses responsible for hand, foot and mouth disease, and plays a key role in cell entry2. The isolated structures of EV71 and SCARB2 are known3,4,5,6, but how they interact to initiate infection is not. Here, we report the EV71–SCARB2 complex structure determ...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/s41564-018-0319-z

Authors


More by this author
Institution:
Linacre College
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0002-7188-5243
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0001-8916-8552
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Role:
Author
ORCID:
0000-0002-4480-5439
More by this author
Institution:
St Edmund Hall
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Structural Biology
Role:
Author
ORCID:
0000-0001-9754-5303
Expand authors...
More from this funder
Funding agency for:
Fry, E
Grant:
MR/N00065X/1
More from this funder
Funding agency for:
Ren, J
Grant:
101122/Z/13/Z
More from this funder
Funding agency for:
Stuart, D
Grant:
MR/N00065X/1
Expand funders...
Publisher:
Springer Nature Publisher's website
Journal:
Nature Microbiology Journal website
Volume:
4
Pages:
414–419
Publication date:
2018-12-10
Acceptance date:
2018-09-09
DOI:
EISSN:
2058-5276
Source identifiers:
952200
Language:
English
Pubs id:
pubs:952200
UUID:
uuid:5affbd2b-fbc1-4570-a086-0d403cc9b084
Local pid:
pubs:952200
Deposit date:
2018-12-13

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP