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Phenotypic dissection of the mouse Ren-1d knockout by complementation with human renin

Abstract:

Normal renin synthesis and secretion is important for the maintenance of juxtaglomerular apparatus architecture. Mice lacking a functional Ren-1d gene are devoid of renal juxtaglomerular cell granules and exhibit an altered macula densa morphology. Due to the species-specificity of renin activity, transgenic mice are ideal models for experimentally investigating and manipulating expression patterns of the human renin gene in a native cellular environment without confounding Renin-angiotensin-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1074/jbc.ra117.000160

Authors


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Funding agency for:
Buckley, C
Grant:
RE/08/001/23904
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Funding agency for:
Nelson, RJ
Grant:
WT052633MA
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Funding agency for:
Peti-Peterdi, J
Grant:
1 S10 OD021833
Publisher:
American Society for Biochemistry and Molecular Biology Publisher's website
Journal:
Journal of Biological Chemistry Journal website
Volume:
293
Issue:
4
Pages:
1151-1162
Publication date:
2017-11-09
Acceptance date:
2017-11-09
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Pmid:
29123029
Source identifiers:
745971
Language:
English
Keywords:
Pubs id:
pubs:745971
UUID:
uuid:5b296da4-eb32-46a2-8f17-746f3a8c5701
Local pid:
pubs:745971
Deposit date:
2018-01-10

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