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In vitro downregulated hypoxia transcriptome is associated with poor prognosis in breast cancer

Abstract:

BACKGROUND: Hypoxia is a characteristic of breast tumours indicating poor prognosis. Based on the assumption that those genes which are up-regulated under hypoxia in cell-lines are expected to be predictors of poor prognosis in clinical data, many signatures of poor prognosis were identified. However, it was observed that cell line data do not always concur with clinical data, and therefore conclusions from cell line analysis should be considered with caution. As many transcriptomic cell-line...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12943-017-0673-0

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Plant Sciences
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Oxford college:
St Hugh's College
Role:
Author
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Funding agency for:
Abu-Jamous, B
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Funding agency for:
Buffa, F
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Funding agency for:
Buffa, F
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Funding agency for:
Harris, A
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Publisher:
BioMed Central Publisher's website
Journal:
Molecular Cancer Journal website
Volume:
16
Issue:
1
Article number:
105
Publication date:
2017-06-15
Acceptance date:
2017-06-02
DOI:
ISSN:
1476-4598
Source identifiers:
701810
Language:
English
Keywords:
Pubs id:
pubs:701810
UUID:
uuid:5b35c95a-012f-4822-9f49-cc8246488f16
Local pid:
pubs:701810
Deposit date:
2017-07-25

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