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Journal article : Letter

N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells

Abstract:

R-loops are nucleic acid structures formed by an RNA:DNA hybrid and unpaired single-stranded DNA that represent a source of genomic instability in mammalian cells1,2,3,4. Here we show that N6-methyladenosine (m6A) modification, contributing to different aspects of messenger RNA metabolism5,6, is detectable on the majority of RNA:DNA hybrids in human pluripotent stem cells. We demonstrate that m6A-containing R-loops accumulate during G2/M and are depleted at G0/G1 phases of the cell cycle, and...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41588-019-0549-x

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Role:
Author
ORCID:
0000-0001-5043-5529
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Institution:
University of Oxford
Department:
Pathology Dunn School
Role:
Author
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Role:
Author
ORCID:
0000-0001-5107-6513
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John Fell Fund More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Genetics Journal website
Volume:
52
Issue:
1
Pages:
48–55
Publication date:
2019-12-16
Acceptance date:
2019-11-13
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
Pmid:
31844323
Source identifiers:
1063557
Language:
English
Keywords:
Subtype:
Letter
Pubs id:
pubs:1063557
UUID:
uuid:5b3b6f65-bf96-40a8-ade8-f4ba4da78ed1
Local pid:
pubs:1063557
Deposit date:
2020-01-16

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