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Journal article

Mutational signatures of ionizing radiation in second malignancies

Abstract:

Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizing radiation in 12 radiation-associated second malignancies of different tumour types. Two signatures of somatic mutation characterize ionizing radiation exposure irrespective of tumour type. Compared with 319 radiation-naive tumours, radiation-ass...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms12605

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
ORCID:
0000-0002-7572-3196
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Role:
Author
ORCID:
0000-0002-0469-1043
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Skeletal Cancer Action Trust More from this funder
Royal National Orthopaedic Hospital NHS Trust More from this funder
Bone Cancer Research Trust More from this funder
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
7
Article number:
12605
Publication date:
2016-09-12
Acceptance date:
2016-07-13
DOI:
ISSN:
2041-1723
Pmid:
27615322
Source identifiers:
643881
Language:
English
Keywords:
Pubs id:
pubs:643881
UUID:
uuid:5b69a5d4-689f-4fc2-b01d-f4df98140415
Local pid:
pubs:643881
Deposit date:
2018-05-09

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