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Strategies in the design and use of synthetic "internal glycan" vaccines

Abstract:

The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/bs.mie.2017.06.008

Authors


More by this author
Institution:
University of Oxford
Division:
MPLS Division
Department:
Chemistry; Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Oxford college:
Pembroke College
Role:
Author
Publisher:
Elsevier Publisher's website
Volume:
597
Pages:
335-357
Host title:
Methods in Enzymology
Publication date:
2017-09-08
DOI:
ISSN:
0076-6879
Pmid:
28935110
Source identifiers:
730700
ISBN:
9780128114698
Language:
English
Keywords:
Pubs id:
pubs:730700
UUID:
uuid:5b6f4aa5-e19a-4360-b011-f28f702f9328
Local pid:
pubs:730700
Deposit date:
2017-10-05

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