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Journal article

A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions

Abstract:

Self-interacting chromatin domains encompass genes and their cis-regulatory elements; however, the three-dimensional form a domain takes, whether this relies on enhancer-promoter interactions, and the processes necessary to mediate the formation and maintenance of such domains, remain unclear. To examine these questions, here we use a combination of high-resolution chromosome conformation capture, a non-denaturing form of fluorescence in situ hybridisation and super-resolution imaging to stud...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-018-06248-4

Authors


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Role:
Author
ORCID:
0000-0002-8884-2047
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Role:
Author
ORCID:
0000-0002-5091-3604
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
RDM Clinical Laboratory Sciences
Oxford college:
Hertford College
Role:
Author
ORCID:
0000-0003-2685-4226
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
Weatherall Inst of Molecular Medicine
Role:
Author
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Funding agency for:
Hughes, J
Grant:
MR/N00969X/1
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Funding agency for:
Higgs, D
Grant:
106130/Z/14/Z
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Funding agency for:
Higgs, D
Grant:
106130/Z/14/Z
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Issue:
1
Pages:
3849
Publication date:
2018-09-21
Acceptance date:
2018-08-24
DOI:
EISSN:
2041-1723
ISSN:
2041-1723
Pmid:
30242161
Source identifiers:
922042
Language:
English
Keywords:
Pubs id:
pubs:922042
UUID:
uuid:5bb0d411-d5b7-4d5b-805c-ea5c5dbe321e
Local pid:
pubs:922042
Deposit date:
2018-11-14

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