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Effects of aspirin on dementia and cognitive function in diabetic patients: the ASCEND trial

Abstract:

Aims Aspirin is widely used in cardiovascular disease prevention but is also associated with an increased risk of bleeding. The net effect of aspirin on dementia and cognitive impairment is uncertain. Methods and results In the ASCEND trial, 15 480 people from the UK with diabetes and no history of cardiovascular disease were randomized to aspirin 100 mg daily or matching placebo for a mean of 7.4 years. The 15 427 ASCEND participants with no recorded dementia prior to baseline were included...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1093/eurheartj/ehac179

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
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Role:
Author
ORCID:
0000-0003-0562-3963
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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Clinical Trial Service Unit
Role:
Author
ORCID:
0000-0002-3367-3207
More by this author
Role:
Author
ORCID:
0000-0002-6534-6307
More by this author
Role:
Author
ORCID:
0000-0003-0971-3026
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Contributors

Medical Research Council More from this funder
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Grant:
SP/08/010/25939
SP/14/3/31114
Publisher:
Oxford University Press Publisher's website
Journal:
European Heart Journal Journal website
Volume:
43
Issue:
21
Pages:
2010-2019
Publication date:
2022-04-08
Acceptance date:
2022-03-22
DOI:
EISSN:
1522-9645
ISSN:
0195-668X
Pmid:
35393614
Language:
English
Keywords:
Pubs id:
1250674
Local pid:
pubs:1250674
Deposit date:
2022-05-17

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