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Thesis

Cell replacement and ex vivo gene therapy for photoreceptor regeneration

Abstract:

Photoreceptor degeneration due to retinitis pigmentosa (RP) is a primary cause of inherited retinal blindness. Photoreceptor cell-replacement therapies may hold the potential for repair in a degenerate retina, by reinstating light sensitive cells to project and form connections with downstream retinal cells and finally the visual cortex. Patient-specific induced pluripotent stem cells (iPSc) could provide an autologous source of cells to replace lost tissue. However, the use of patient-der...

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Division:
MSD
Department:
Clinical Neurosciences
Department:
University of Oxford
Role:
Author

Contributors

Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Clarendon Fund More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
UUID:
uuid:5bc3f3a6-8ab0-4218-9ab1-19577552160b
Deposit date:
2015-11-12

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