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Cross-cancer genome-wide analysis of lung, ovary, breast, prostate, and colorectal cancer reveals novel pleiotropic associations

Abstract:

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-stage approach to conduct genome-wide association studies for lung, ovary, breast, prostate, and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-3698-6241
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
76
Issue:
17
Pages:
5103-5114
Publication date:
2016-04-20
Acceptance date:
2016-04-05
DOI:
ISSN:
0008-5472 and 1538-7445
Pmid:
27197191
Source identifiers:
623144
Language:
English
Keywords:
Pubs id:
pubs:623144
UUID:
uuid:5bc88bb2-2b41-4193-b08c-f702a503113c
Local pid:
pubs:623144
Deposit date:
2019-04-05

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