Journal article
Purine metabolism controls innate lymphoid cell function and protects against intestinal injury
- Abstract:
-
Inflammatory bowel disease (IBD) is a condition of chronic inflammatory intestinal disorder with increasing prevalence but limited effective therapies. The purine metabolic pathway is involved in various inflammatory processes including IBD. However, the mechanisms through which purine metabolism modulates IBD remain to be established. Here, we found that mucosal expression of genes involved in the purine metabolic pathway is altered in patients with active ulcerative colitis (UC), which is a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Authors
Funding
+ European Union
More from this funder
Funding agency for:
Ghazal, P
Satsangi, J
Grant:
BB/K091121/1
305479-2
+ Biotechnology and Biological Sciences Research Council
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Funding agency for:
Ghazal, P
Grant:
BB/K091121/1
+ Medical Research Council
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Funding agency for:
Ho, GT
Ruckerl, D
Rossi, AG
Anderton, SM
Yao, C
Grant:
MR/K013386/1
MR/K013386/1
MR/K013386/1
MR/K013386/1
C63480/A25246
Bibliographic Details
- Publisher:
- Wiley Publisher's website
- Journal:
- Immunology and Cell Biology Journal website
- Volume:
- 96
- Issue:
- 10
- Pages:
- 1049-1059
- Publication date:
- 2018-05-14
- Acceptance date:
- 2018-05-07
- DOI:
- ISSN:
-
0818-9641 and 1440-1711
Item Description
- Keywords:
- Pubs id:
-
pubs:894291
- UUID:
-
uuid:5be0e471-4436-49cb-b0d3-c85b601c51e2
- Local pid:
- pubs:894291
- Source identifiers:
-
894291
- Deposit date:
- 2018-08-07
Terms of use
- Copyright holder:
- University of Edinburgh Immunology and Cell Biology published by John Wiley and Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc
- Copyright date:
- 2018
- Notes:
- © 2018 University of Edinburgh Immunology and Cell Biology published by John Wiley and Sons Australia, Ltd on behalf of Australasian Society for Immunology Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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