Journal article
Direct transcriptional consequences of somatic mutation in breast cancer.
- Abstract:
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The disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription; co-ordinated secondary alterations in transcriptional pathways; and increased transcriptional noise. To catalogue the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive bioinformatics pipeline for analyzing RNA-sequencing data, which we integrated with whole genome sequencing from 23 breast cancers. Using X-inactivation analyses, we find ca...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 1.6MB)
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- Publisher copy:
- 10.1016/j.celrep.2016.07.028
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Authors
Funding
National Research Council Canada
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Rep Journal website
- Volume:
- 16
- Issue:
- 7
- Pages:
- 2032-2046
- Publication date:
- 2016-08-01
- Acceptance date:
- 2016-07-14
- DOI:
- ISSN:
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2211-1247
- Source identifiers:
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652952
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:652952
- UUID:
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uuid:5c0ef293-dea4-411b-ae4f-6ff96d016c2e
- Local pid:
- pubs:652952
- Deposit date:
- 2016-11-18
Terms of use
- Copyright holder:
- Wedge et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Authors. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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