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Journal article

Direct transcriptional consequences of somatic mutation in breast cancer.

Abstract:

The disordered transcriptomes of cancer encompass direct effects of somatic mutation on transcription; co-ordinated secondary alterations in transcriptional pathways; and increased transcriptional noise. To catalogue the rules governing how somatic mutation exerts direct transcriptional effects, we developed an exhaustive bioinformatics pipeline for analyzing RNA-sequencing data, which we integrated with whole genome sequencing from 23 breast cancers. Using X-inactivation analyses, we find ca...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2016.07.028

Authors


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National Research Council Canada More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cell Rep Journal website
Volume:
16
Issue:
7
Pages:
2032-2046
Publication date:
2016-08-01
Acceptance date:
2016-07-14
DOI:
ISSN:
2211-1247
Source identifiers:
652952
Language:
English
Keywords:
Pubs id:
pubs:652952
UUID:
uuid:5c0ef293-dea4-411b-ae4f-6ff96d016c2e
Local pid:
pubs:652952
Deposit date:
2016-11-18

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