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Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors

Abstract:

The human 2-oxoglutarate dependent oxygenase aspartate/asparagine-β-hydroxylase (AspH) catalyses the hydroxylation of Asp/Asn-residues in epidermal growth factor-like domains (EGFDs). AspH is upregulated on the surface of malign cancer cells; increased AspH levels correlate with tumour invasiveness. Due to a lack of efficient assays to monitor the activity of isolated AspH, there are few reports of studies aimed at identifying small-molecule AspH inhibitors. Recently, it was reported that Asp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-020-65123-9

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0002-0290-6565
Publisher:
Nature Research Publisher's website
Journal:
Scientific Reports Journal website
Volume:
10
Article number:
8650
Publication date:
2020-05-26
Acceptance date:
2020-04-27
DOI:
EISSN:
2045-2322
Language:
English
Keywords:
Pubs id:
1102198
Local pid:
pubs:1102198
Deposit date:
2020-04-28

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