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Metabolic Mediators of the association between adult weight gain and Colorectal cancer: Data from European prospective investigation into Cancer and nutrition (EPIC) Cohort

Abstract:

Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relation between adult weight gain and colorectal cancer using data from a prospective nested case-control study among 452 incident cases diagnosed between 1992 and 2003, and matched within risk sets to 452 controls within the European Pr...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/aje/kww194

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Cancer Epidemiology Unit
Role:
Author
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Cancer Research UK More from this funder
Stroke Association More from this funder
Medical Research Council More from this funder
British Heart Foundation More from this funder
Department of Health More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
American Journal of Epidemiology Journal website
Volume:
185
Issue:
91
Pages:
751–764
Publication date:
2017-04-06
Acceptance date:
2016-04-01
DOI:
EISSN:
1476-6256
ISSN:
0002-9262
Source identifiers:
615002
Keywords:
Pubs id:
pubs:615002
UUID:
uuid:5c29667d-5409-4e4e-822a-0329934f5e2e
Local pid:
pubs:615002
Deposit date:
2016-04-13

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