Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.

Journal article

CD4(+)CD25(+)Foxp3(+) natural regulatory T cells (T reg cells) maintain self-tolerance and suppress autoimmune diseases such as type 1 diabetes and inflammatory bowel disease (IBD). In addition to their effects on T cells, T reg cells are essential for maintaining normal numbers of dendritic cells (DCs): when T reg cells are depleted, there is a compensatory Flt3-dependent increase in DCs. However, little is known about how T reg cell homeostasis is maintained in vivo. We demonstrate the exis...

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Authors: Darrasse-Jèze, G; Deroubaix, S; Mouquet, H; Victora, G; Eisenreich, T

• Journal: Journal of experimental medicine
• Volume: 206
• Issue: 9
• Pages: 1853-1862
• Publication date: 2009-08-01
• DOI: 10.1084/jem.20090746
• EISSN: 1540-9538
• ISSN: 0022-1007
• Language: English
• Keywords: Homeostasis; Feedback; T-Lymphocytes, Regulatory; Inflammatory Bowel Diseases; Cytokines; Animals; Dendritic Cells; Flow Cytometry; Mice; Antibodies, Monoclonal; Cell Proliferation; Mice, Transgenic; Mice, Inbred NOD; Forkhead Transcription Factors; Genes, MHC Class II; Diabetes Mellitus, Type 1; Regression Analysis