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Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.

Abstract:

CD4(+)CD25(+)Foxp3(+) natural regulatory T cells (T reg cells) maintain self-tolerance and suppress autoimmune diseases such as type 1 diabetes and inflammatory bowel disease (IBD). In addition to their effects on T cells, T reg cells are essential for maintaining normal numbers of dendritic cells (DCs): when T reg cells are depleted, there is a compensatory Flt3-dependent increase in DCs. However, little is known about how T reg cell homeostasis is maintained in vivo. We demonstrate the exis...

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Publisher copy:
10.1084/jem.20090746

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Journal:
Journal of experimental medicine
Volume:
206
Issue:
9
Pages:
1853-1862
Publication date:
2009-08-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
426293

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