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Journal article

Re-sequencing expands our understanding of the phenotypic impact of variants at GWAS loci

Abstract:

Genome-wide association studies (GWAS) have identified >500 common variants associated with quantitative metabolic traits, but in aggregate such variants explain at most 20–30% of the heritable component of population variation in these traits. To further investigate the impact of genotypic variation on metabolic traits, we conducted re-sequencing studies in >6,000 members of a Finnish population cohort (The Northern Finland Birth Cohort of 1966 [NFBC]) and a type 2 diabetes case-contro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pgen.1004147

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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS Genetics Journal website
Volume:
10
Issue:
1
Pages:
ARTN e1004147
Publication date:
2014-01-30
Acceptance date:
2013-12-16
DOI:
EISSN:
1553-7404
ISSN:
1553-7390
Source identifiers:
447724
Language:
English
Keywords:
Pubs id:
pubs:447724
UUID:
uuid:5c4c3b1e-41c7-427b-8d5c-18b53726ce46
Local pid:
pubs:447724
Deposit date:
2014-05-13

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