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N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

Abstract:

Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic disorders, or it may occur in the absence of metabolic abnormalities. In addition, EC may be inherited as part of several monogenic disorders and studies of these have provided valuable insights into the metabolic pathways regulating mineral metabolism. For example, studies of tumoural calcinosis, a disorder character...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Grant:
G0600702/1,G9825289
G1000467
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE
Volume:
10
Issue:
4
Publication date:
2015-04-10
Acceptance date:
2015-02-11
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Language:
English
UUID:
uuid:5ca1b65f-3530-44eb-a0ba-0f0f9f964ba8
Deposit date:
2015-05-28

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