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Global sleep homeostasis reflects temporally and spatially integrated local cortical neuronal activity

Abstract:

Sleep homeostasis manifests as a relative constancy of its daily amount and intensity. Theoretical descriptions define 'Process S', a variable with dynamics dependent on global sleep-wake history, and reflected in electroencephalogram (EEG) slow wave activity (SWA, 0.5-4 Hz) during sleep. The notion of sleep as a local, activity-dependent process suggests that activity history must be integrated to determine the dynamics of global Process S. Here, we developed novel mathematical models of Pro...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.7554/elife.54148

Authors


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Role:
Author
ORCID:
0000-0001-5371-7257
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Role:
Author
ORCID:
0000-0002-8611-3852
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Division:
MSD
Sub department:
AV PHYSIOLOGY ANATOMY AND GENETICS; Sleep and Metabolism
Role:
Author
ORCID:
0000-0003-3085-1175
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Role:
Author
ORCID:
0000-0002-0208-3511
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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Oxford college:
Balliol College
Role:
Author
ORCID:
0000-0002-4336-6681
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
eLife Sciences Publications Publisher's website
Journal:
eLife Journal website
Volume:
9
Article number:
e54148
Publication date:
2020-07-02
Acceptance date:
2020-06-19
DOI:
EISSN:
2050-084X
ISSN:
2050-084X
Pmid:
32614324
Language:
English
Keywords:
Pubs id:
1116383
Local pid:
pubs:1116383
Deposit date:
2020-07-08

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