Journal article
Phenotypic evolutionary models in stem cell biology: replacement, quiescence, and variability
- Abstract:
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Phenotypic evolutionary models have been used with great success in many areas of biology, but thus far have not been applied to the study of stem cells except for investigations of cancer. We develop a framework that allows such modeling techniques to be applied to stem cells more generally. The fundamental modeling structure is the stochastic kinetics of stem cells in their niche and of transit amplifying and fully differentiated cells elsewhere in the organism, with positive and negative f...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 416.3KB)
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- Publisher copy:
- 10.1371/journal.pone.0001591
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Authors
Funding
National Science Foundation (NSF)
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Royal Society
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Astor Travel Fund, University of Oxford
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Bibliographic Details
- Publisher:
- Public Library of Science Publisher's website
- Journal:
- PLoS ONE Journal website
- Volume:
- 3
- Issue:
- 2
- Article number:
- e1591
- Publication date:
- 2008-02-01
- DOI:
- EISSN:
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1932-6203
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
-
uuid:5cca5ef4-5d1f-4741-bc7d-32cb8cd325d3
- Local pid:
- ora:2841
- Deposit date:
- 2009-07-06
Related Items
Terms of use
- Copyright holder:
- M Mangel & M B Bonsall
- Copyright date:
- 2008
- Notes:
- Citation: Mangel, M. & Bonsall, M. B. (2008). 'Phenotypic evolutionary models in stem cell biology: replacement, quiescence, and variability', PLoS ONE 3(2), e1591. [Available at http://www.plosone.org]. © 2008 Mangel, Bonsall. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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