Journal article
Constitutive IDO1 expression in human tumors is driven by cyclooxygenase-2 and mediates intrinsic immune resistance.
- Abstract:
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Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expression of indoleamine 2,3-dioxygenase 1 (IDO1) in human tumor cells. IDO1 is an immunosuppressive enzyme that degrades tryptophan. In a series of seven human tumor lines, constitutive IDO1 expression depends on COX-2 and prostaglandin E2 (PGE2), w...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Accepted manuscript, pdf, 7.7MB)
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(Accepted manuscript, pdf, 9.2MB)
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(Accepted manuscript, pdf, 363.3KB)
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- Publisher copy:
- 10.1158/2326-6066.cir-16-0400
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Authors
Funding
Walloon Excellence in Life Sciences and Biotechnology
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Ludwig Cancer Research
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Belgian National Fund for Scientific Research
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Belgian Foundation Against Cancer
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de Duve Institute
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Bibliographic Details
- Publisher:
- American Association for Cancer Research Publisher's website
- Journal:
- Cancer Immunology Research Journal website
- Volume:
- 5
- Issue:
- 8
- Pages:
- 695-709
- Publication date:
- 2017-07-01
- Acceptance date:
- 2017-06-30
- DOI:
- EISSN:
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2326-6074
- ISSN:
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2326-6066
- Pmid:
-
28765120
- Source identifiers:
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829358
Item Description
- Language:
- English
- Keywords:
- Pubs id:
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pubs:829358
- UUID:
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uuid:5cd954c9-0a93-414c-ae86-8fae825a9af0
- Local pid:
- pubs:829358
- Deposit date:
- 2018-03-14
Terms of use
- Copyright holder:
- American Association for Cancer Research
- Copyright date:
- 2017
- Notes:
- ©2017 American Association for Cancer Research. This is the accepted manuscript version of the article. The final version is available online from American Association for Cancer Research at: https://doi.org/10.1158/2326-6066.CIR-16-0400
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