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Journal article

Constitutive IDO1 expression in human tumors is driven by cyclooxygenase-2 and mediates intrinsic immune resistance.

Abstract:

Tumors use various mechanisms to avoid immune destruction. Cyclooxygenase-2 (COX-2) expression may be a driver of immune suppression in melanoma, but the mechanisms involved remain elusive. Here, we show that COX-2 expression drives constitutive expression of indoleamine 2,3-dioxygenase 1 (IDO1) in human tumor cells. IDO1 is an immunosuppressive enzyme that degrades tryptophan. In a series of seven human tumor lines, constitutive IDO1 expression depends on COX-2 and prostaglandin E2 (PGE2), w...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1158/2326-6066.cir-16-0400

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Role:
Author
ORCID:
0000-0003-4324-4681
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Walloon Excellence in Life Sciences and Biotechnology More from this funder
Ludwig Cancer Research More from this funder
Belgian National Fund for Scientific Research More from this funder
Belgian Foundation Against Cancer More from this funder
de Duve Institute More from this funder
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Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Immunology Research Journal website
Volume:
5
Issue:
8
Pages:
695-709
Publication date:
2017-07-01
Acceptance date:
2017-06-30
DOI:
EISSN:
2326-6074
ISSN:
2326-6066
Pmid:
28765120
Source identifiers:
829358
Language:
English
Keywords:
Pubs id:
pubs:829358
UUID:
uuid:5cd954c9-0a93-414c-ae86-8fae825a9af0
Local pid:
pubs:829358
Deposit date:
2018-03-14

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