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Short communication: broader T cell responses directed against human immunodeficiency virus type 1 in infected Chinese individuals through blood-borne transmission in comparison with mucosal transmission.

Abstract:

Cellular immune responses play a critical role in the control of human immunodeficiency virus type 1 (HIV-1), but less is known about the impact of transmission routes on immune defenses against HIV-1. Here, we report that subjects infected with HIV-1 through contaminated blood showed stronger HIV-specific T cell responses than those infected through mucosa, both in breadth (6.9±2.5 vs. 2.3±0.5, p=0.0293) and in magnitude [1270.0±544.9 vs. 409.5±121.3 SFU per million peripheral blood mononucl...

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Publication status:
Published

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Publisher copy:
10.1089/aid.2011.0314

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Journal:
AIDS research and human retroviruses
Volume:
29
Issue:
1
Pages:
89-93
Publication date:
2013-01-01
DOI:
EISSN:
1931-8405
ISSN:
0889-2229
Source identifiers:
334905
Language:
English
Keywords:
Pubs id:
pubs:334905
UUID:
uuid:5cdbadf7-0320-4b06-ac13-6331009d951f
Local pid:
pubs:334905
Deposit date:
2013-11-16

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