Short communication: broader T cell responses directed against human immunodeficiency virus type 1 in infected Chinese individuals through blood-borne transmission in comparison with mucosal transmission.

Journal article

Cellular immune responses play a critical role in the control of human immunodeficiency virus type 1 (HIV-1), but less is known about the impact of transmission routes on immune defenses against HIV-1. Here, we report that subjects infected with HIV-1 through contaminated blood showed stronger HIV-specific T cell responses than those infected through mucosa, both in breadth (6.9±2.5 vs. 2.3±0.5, p=0.0293) and in magnitude [1270.0±544.9 vs. 409.5±121.3 SFU per million peripheral blood mononucl...

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Authors: Zhou, D; Zhang, X; Li, W; Xu, X; Goonetilleke, N

• Publication status: Published
• Journal: AIDS research and human retroviruses
• Volume: 29
• Issue: 1
• Pages: 89-93
• Publication date: 2013-01-01
• DOI: 10.1089/aid.2011.0314
• EISSN: 1931-8405
• ISSN: 0889-2229
• Language: English
• Keywords: Male; Female; Immunity, Cellular; Substance Abuse, Intravenous; HIV-1; Blood Transfusion; CD4 Lymphocyte Count; China; T-Lymphocytes; Humans; Enzyme-Linked Immunosorbent Assay; HIV Infections