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Thesis

Antibodies directed against AMPA and GABAB receptors in neurological diseases and identification of novel antigen targets

Abstract:

Antibodies directed against AMPAR and GABABR subunits have been implicated in forms of limbic encephalitis (LE), a disease characterised by memory loss and seizures. Patients with LE show clinical improvement with immunomodulatory treatment, suggesting that the associated antibodies are pathogenic. To explore further the AMPAR and GABABR antibodies, an in house cell based assay (CBA) was established for screening and potential pathogenicity was explored using a series...

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Research group:
Nuffield Department of Clinical Neurosciences
Department:
Medical Sciences Division - Clinical Neurology
Role:
Author
More by this author
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author

Contributors

Division:
MSD
Department:
Clinical Neurosciences
Role:
Supervisor
Publication date:
2014
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:5d3eb5fa-9f51-4415-92bd-2d7c795aa51c
Local pid:
ora:10143
Deposit date:
2015-02-20

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