Journal article icon

Journal article

No additional prognostic value for MRE11 in squamous cell carcinomas of the anus treated with chemo-radiotherapy

Abstract:

Background: The majority of anal cancers (84-95%) are driven by infection with human papillomavirus (HPV). HPV-positive tumours show significantly better responses to chemoradiotherapy when compared to HPV-negative tumours. HPV infection is linked to alterations in DNA damage response proteins, including MRE11. MRE11 is a potential predictive biomarker for response to radiotherapy in muscle-invasive bladder cancer and may hold predictive power in other cancers.

Methods: Using a prev...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1038/bjc.2017.188

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
Expand authors...
More from this funder
Funding agency for:
Kiltie, A
Grant:
C5255/A15935
Publisher:
Cancer Research UK Publisher's website
Journal:
British Journal of Cancer Journal website
Volume:
117
Pages:
322-325
Publication date:
2017-06-22
Acceptance date:
2017-05-30
DOI:
EISSN:
1532-1827
ISSN:
0007-0920
Source identifiers:
697660
Keywords:
Pubs id:
pubs:697660
UUID:
uuid:5d8ba69d-5a26-40a1-8f8a-774184e1e44b
Local pid:
pubs:697660
Deposit date:
2017-05-30

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP