Journal article
Carbene footprinting reveals binding interfaces of a multimeric membrane‐spanning protein
- Abstract:
-
Mapping the interaction sites between membrane‐spanning proteins is a key challenge in structural biology. In this study a carbene‐footprinting approach was developed and applied to identify the interfacial sites of a trimeric, integral membrane protein, OmpF, solubilised in micelles. The diazirine‐based footprinting probe is effectively sequestered by, and incorporated into, the micelles, thus leading to efficient labelling of the membrane‐spanning regions of the protein upon irradiation at ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1002/anie.201708254
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Authors
Funding
University of Nottingham
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Bibliographic Details
- Publisher:
- Wiley‐VCH Verlag Publisher's website
- Journal:
- Angewandte Chemie (International ed. in English) Journal website
- Volume:
- 56
- Issue:
- 47
- Pages:
- 14873-14877
- Publication date:
- 2017-10-20
- Acceptance date:
- 2017-09-27
- DOI:
- EISSN:
-
1521-3773
- ISSN:
-
1433-7851
- Pmid:
-
28960650
- Source identifiers:
-
732518
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:732518
- UUID:
-
uuid:5d945bf0-6e65-4c89-b0eb-bf351569c682
- Local pid:
- pubs:732518
- Deposit date:
- 2018-08-10
Terms of use
- Copyright holder:
- Wiley‐VCH Verlag GmbH & Co KGaA, Weinhei
- Copyright date:
- 2017
- Notes:
- Copyright © 2017 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim.
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