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Journal article

The MITF regulatory network in melanoma

Abstract:

Bidirectional interactions between plastic tumor cells and the microenvironment critically impact tumor evolution and metastatic dissemination by enabling cancer cells to adapt to microenvironmental stresses by switching phenotype. In melanoma, a key determinant of phenotypic identity is the microphthalmia-associated transcription factor MITF that promotes proliferation, suppresses senescence, and anticorrelates with immune infiltration and therapy resistance. What determines whether MITF can...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1111/pcmr.13053

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
ORCID:
0000-0003-4210-6260
More by this author
Role:
Author
ORCID:
0000-0002-1614-3909
Cancer Research UK More from this funder
Publisher:
Wiley Publisher's website
Journal:
Pigment Cell and Melanoma Research Journal website
Publication date:
2022-07-09
Acceptance date:
2022-06-28
DOI:
EISSN:
1755-148X
ISSN:
1755-1471
Pmid:
35771179
Language:
English
Keywords:
Pubs id:
1267114
Local pid:
pubs:1267114
Deposit date:
2022-07-29

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